Carlos Alcaraz and Novak Djokovic will face potential difficult American opponents when they begin their quest for another US Open title.

Jannik Sinner, of Italy, holds up the championship trophy after defeating Taylor Fritz, of the United States, in the men's singles final of the U.S. Open tennis championships, Sept. 8, 2024, in New York. Credit: AP/Julia Nikhinson

Carlos Alcaraz faces a challenging US Open 2025 path, with a potential semi-final clash against Novak Djokovic looming. The Spaniard must navigate a tough quarter packed with stars like Daniil Medvedev,