Christian McCaffrey is dealing with a stiff back ahead of Week 18. Here's the latest injury update on the 49ers RB.

For the 49ers, left tackle Trent Williams and defensive end Keion White were non-participants for the second consecutive day as they are dealing lower body injuries. Two key members of San Francisco's backfield, Christian McCaffrey and Kyle Juszczyk, returned as limited participants after not participating on Tuesday.

Week 18 vs Seahawks as Christian McCaffrey, Trent Williams, and George Kittle push to return for San Francisco.

Week 17 of the NFL season is underway, and there are some key players dealing with injuries. Here's who's in and who's out.

San Francisco star tight end George Kittle will miss the 49ers' key game in playoff positioning on Sunday night against the Chicago Bears with an ankle injury. Kittle missed the full week of practice after getting hurt Monday night in a win against Indianapolis and was unable to go in a game the 49ers (11-4) needed to

Kittle and Pearsall questionable while Green is out as San Francisco preps for Week 17 SNF matchup vs Chicago Bears.

After a wild back-and-forth affair with the Chicago Bears this past Sunday that saw the San Francisco 49ers maintain control of their own destiny with a 42-38 victory, Kyle Shanahan & Co. are now set for a winner-take-all Week 18 showdown with the Seattle Seahawks this Saturday night that will determine both the NFC West and the No.