Teams that have started Sam Darnold have gone 27-6 in the past two seasons. However, the Minnesota Vikings saw Darnold start to fade before his worst two games closed out the season and the San Francisco 49ers are hoping to get the same outcome in Week 18 this year .

Seattle presents many challenges, but one of the most difficult matchups is with wide receiver Jaxon Smith-Njigba, who isn’t a household name yet in his third year out of Ohio State but probably should be. The Seahawks felt good enough about him to trade D.K. Metcalf, their No. 1 receiver, to Pittsburgh in the offseason.

According to a Cleveland Browns teammate, the Pittsburgh Steelers weren't the only opponent overly concerned with Myles Garrett.

San Francisco 49ers defensive coordinator Robert Saleh was clear about the issues that would be created if he used man-to-man coverage against Seattle's prolific Jaxon Smith-Njibga.

Wednesday was the second practice day of the week for both teams, and both teams produced a practice report that sheds some light on who will be available this weekend.

Sam Farmer makes his picks and predictions for the final week of the NFL regular season, with the 49ers beat the Seahawks and the Steelers prevailing.

The San Francisco 49ers will face the Seattle Seahawks in Week 18, and cornerback Deommodore Lenoir already knows what he wants his assignment to be.

The Bears and 49ers proved Sunday night that they have the offensive horsepower to go that deep in the postseason, engaging in a duel at Levi’s Stadium that featured 936 total yards, 58 first downs and 10 offensive touchdowns.

Jauan Jennings and Brock Purdy, the 49ers’ seventh-round superstars, are a red-hot tandem entering Saturday night’s game against Seattle for the NFC playoffs’ top seed.

Brock Purdy threw for 303 yards and three touchdowns as San Francisco is now one win away from earning the NFC's top seed.

Chicago Bears tight end Colston Loveland had a great response to the team's rough loss to the San Francisco 49ers.

Christian McCaffrey, Trent Williams, Keion White and Kyle Juszczyk are not practicing Tuesday ahead of the 49ers’ regular-season finale against Seattle.