Adenylosuccinate lyase (ADSL) deficiency is an inherited metabolic disorder that impairs purine metabolism. ADSL is a key enzyme in both the de novo synthesis and the purine nucleotide cycle, ...
While most enzymatic activity is conducted through chemical binding interactions between molecules, in some cases, the mere presence of an enzyme can affect intracellular functions. While exploring ...
Parkinson's disease (PD), the second most common neurodegenerative disorder globally, has long baffled scientists with its progressive nature and debilitating effects on motor function. A recent study ...
Scientists have developed a new computational tool that maps multi-gene pathways more comprehensively than ever before. The ...
Gut microbiota capable of metabolizing uric acid and purines may play a key role in reducing gout diagnoses, and although the findings from new retrospective and prospective studies suggest key roles ...
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The enzyme that doesn't act like one: NUDT5 controls DNA building block production through structure, not catalysis
Inside every cell, a finely tuned metabolic network determines when to build, recycle, or stop producing essential molecules. A central part of this network is folate metabolism, a process that ...
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