With 7:14 to go in the opening quarter, Colts returner Ameer Abdullah received the kickoff and cut inside as Niners safety Ji'Ayir Brown remained under control and redirected to Abdullah. Brown reached in and punched the ball loose as tight end Jake Tonges recovered as Indianapolis' 26. Five plays later, the Niners scored again to take a 14-7 lead.

This game features two of the best running backs the NFL has to offer with Christian McCaffrey leading the 49ers on offense while Jonathan Taylor has had a monster year for the Colts. Taylor leads the league in rushing yards and touchdowns while McCaffrey is 13th in rushing yards and has the sixth-most receptions in the NFL.

SANTA CLARA, Calif. -- After making it through training camp and the preseason with no apparent health issues and not even appearing on Wednesday's injury report, running back Christian McCaffrey was added to the list Thursday night. According to the 49ers ...

Read full article: Florida chills out! Cold blast to send ‘feels-like’ temps below freezing. Here’s the timeline SANTA CLARA, Calif. – Christian McCaffrey maintained that playing Carolina for the first time since the Panthers traded him to San ...

McCaffrey currently has 1,039 rushing yards and 849 receiving yards this season. That puts him in range to record just the fourth season of 1,000 rushing yards and 1,000 receiving yards in NFL history.