Nature

Methods for randomized, blinded, controlled evaluation of putative disease interventions in multilaboratory, preclinical assessment networks

Science faces a reproducibility crisis, and public trust in science declines when large clinical trials, which had been qualified by promising preclinical studies, fail. While some clinical trial ...
Nature

Incorporating health literacy principles into the adaptation of a methods motivational interviewing approach for enrolling black adults in a pilot randomized trial

Suboptimal enrollment and retention efforts can compromise the quality of clinical trials. Barriers to enrolling marginalized populations include low awareness/education about clinical trials. Methods ...
The New England Journal of Medicine

Prehospital Whole Blood in Traumatic Hemorrhage — A Randomized Controlled Trial

Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...