Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

Typically in optical microscopy, the signal-to-noise ratio (SNR) is calculated to quantify the image contrast which indicates how well different regions of interest in the image can be differentiated.

Over the past centuries, optical microscopy has been fundamental for exploring and understanding structural features and sample dynamics. Fluorescence microscopy, developed in the early 20th century, ...