During DNA replication, the two new DNA strands are synthesized asymmetrically, with the leading strand synthesized in a continuous fashion and the lagging strand synthesized as a discontinuous series ...
Together, these results reinforce the notion that PCNA and lagging-strand processes undergo functional exhaustion during unperturbed origin activation and become further depleted upon unscheduled ...
During replication, DNA polymerases are positioned on each strand of DNA . Using a microscope slide as an anchor, we tethered DNA to a bead and stretched it with a flow of solution. We tracked how the ...
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