Yale researchers have provided new insight into how mutations in a single gene may cause mental retardation and kidney problems in Lowe syndrome, a rare genetic condition that affects only boys. Lowe ...

Can-Fite Signed agreement with Fondazione Telethon for co-development of Piclidenoson for the treatment of Lowe syndrome an estimated $100 M market in the U.S. only with no drug available FDA & EMA ...

Ramat Gan, Israel, March 19, 2025 (GLOBE NEWSWIRE) -- Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE:CANF), a biotechnology company advancing a pipeline of proprietary small molecule drugs that ...

Lowe’s syndrome - also known as the cerebrooculorenal syndrome, the oculocerebrorenal syndrome of Lowe, and phosphatidylinositol-4,5-bisphosphate-5-phosphatase deficiency - represents a very rare ...

Can-Fite BioPharma Ltd. has announced the completion of a Phase II study design and is preparing to initiate a clinical study for Piclidenoson, a novel treatment for Lowe Syndrome, a rare genetic ...

Lowe syndrome (LS) is a lethal X-linked genetic disorder caused by caused by mutations in OCRL1 gene, which encodes a lipid phosphatase Ocrl1, important for many cellular processes. Our lab identified ...

Purdue University researchers have developed a patented therapeutic strategy for Lowe syndrome, an incurable and rare genetic disorder, by repurposing two drugs previously approved by the U.S. Food ...

Delayed vitreous haemorrhage is an exceedingly rare complication of cataract surgery; in the paediatric population, it can result in significant visual morbidity. The case presented demonstrates that ...

Lowe syndrome and type 2 Dent disease are caused by defects in the inositol 5-phosphatase OCRL. Most missense mutations in the OCRL ASH-RhoGAP domain that are found in affected individuals abolish ...

Paul James enjoys going to the pub, shopping and horse racing. Quite normal for any 26-year-old you may think, but he has a rare condition called Lowe Syndrome although it doesn't hold him back. My ...