A visualization made from nearly 100,000 electron microscope images has revealed the ingenious way a protein involved in muscle activity shuts itself down to conserve energy. The protein is called ...

At the molecular level, muscle contraction is defined by myosin molecules pulling actin filaments. New electron cryomicroscopy images with unprecedented resolution taken by researchers at Osaka ...

Striated muscle contraction requires intricate interactions of microstructures. The classic textbook assumption that myosin filaments are compressed at the meshed Z-disc during striated muscle fibre ...

Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal muscles. Sarcomeric myosin heavy chain ...

Hypertrophic cardiomyopathy (HCM) is a common genetic disorder characterized by left ventricular hypertrophy and cardiac hyper-contractility. Mutations in the β cardiac myosin heavy chain gene (β-MyHC ...

Danicamtiv is an investigational selective agonist of cardiac myosin, intended to help myocyte contraction by enhancing cardiac myosin function and availability. As such, it is positioned as a ...

During each heartbeat, cardiac contractility results from calcium-activated sliding of actin thin filaments toward the centers of myosin thick filaments to shorten cellular length. Cardiac ...

A research team led by Biological Sciences Asst. Prof. Nicolai Konow will work across disciplines to develop a deeper understanding of how muscles function. “Everything has to be broken down to its ...

Muscle physiologist sought an alternative energy source to replace the body's usual one, adenosine triphosphate (ATP). Such a source could control muscle activity, and might lead to new muscle ...