Overall picks to win: 8-8 in Week 17 (173-82-1 for the season) Picks to win with 1-5 confidence: 4-7 (103-64-1) Picks to win with 6-10 confidence: 4-1 (70-18) Overall to cover the spread: 9-6-1 (130-117-9) Cover-the-spread picks with 1-5 confidence: 8-4-1 (107-93-8) Cover-the-spread picks with 6-10 confidence: 1-2 (23-23-1)

Per ESPN Research: the 2025 Eagles are the first team since the 1987 Patriots to win multiple games in a season in which they didn’t complete a second half pass. Hurts is the first QB in the play by play era (since 1978) to go 0-7 or worse in multiple games in a season.

Following their 20-13 win over the Kansas City Chiefs in Week 17, the Denver Broncos are now considered home favorites going into a regular season finale against the Los Angeles Chargers in Week 18.

Mike Florio and Chris Simms explain why they think the Rams will be motivated by their Week 17 loss to the Falcons, and will close out the regular season strong with a win against the Cardinals.

SportsLine's proven computer model has identified it's top NFL picks for Week 17 divisional rivalry matchups at DraftKings

Week 18 is upon us in the NFL, and the conclusion of the 2025 regular season has many playoff scenarios, including the remaining two spots in the AFC and NFC.