Overall picks to win: 8-8 in Week 17 (173-82-1 for the season) Picks to win with 1-5 confidence: 4-7 (103-64-1) Picks to win with 6-10 confidence: 4-1 (70-18) Overall to cover the spread: 9-6-1 (130-117-9) Cover-the-spread picks with 1-5 confidence: 8-4-1 (107-93-8) Cover-the-spread picks with 6-10 confidence: 1-2 (23-23-1)

This article was originally published on fansided.com as NFL Week 15 picks and predictions, straight-up and ATS: Bills-Patriots, Packers-Broncos lead huge slate.

We make picks for all 16 NFL games with levels of confidence ahead of Week 16. We’re a week away from Christmas and the NFL playoff race is reaching a fevered pitch. We won’t know every playoff spot after this weekend, but we could see most of the playoff berths locked up by the close of 49ers-Colts on Monday.

Entering the final week of the 2025 regular season, an Eagles win over the Commanders and a Bears loss to the Lions would give Philadelphia the No. 2 seed.

The playoff picture is almost set. Here's how the NFL playoff picture looks after the Sunday early afternoon games of Week 18: DIVISION LEADERS 1. Detroit Lions (14-2): Clinched a playoff berth, will clinch the No.