Opioids are still widely prescribed, but have limited effectiveness and are associated with serious harms. De-prescribing ...

In the struggle against the opioid epidemic in the United States, any positive news is welcome. The crisis is acute: the last report from the Department of Health and Human Services, in 2014, found ...

The FDA has made several updates to its opioid prescribing information, including new warnings about the possibility for increased pain, which can lead to dangerous adverse reactions such as ...

Most agree that there is no proven benefit from the chronic use of opioids (Vicodin, Oxycontin, Fentanyl) for non-cancer pain. From the Centers for Disease Control and Prevention, studies show nothing ...

Credit: Thinkstock. A warning about opioid-induced hyperalgesia has been added to the prescribing information. The Food and Drug Administration (FDA) has updated the prescribing information for all ...

Prescription painkillers are creating a massive public-health crisis. Since 1990, deaths in the U.S. from unintentional drug overdoses have increased by over 500%. Most of this rise can be attributed ...

Clonidine is typically prescribed for managing blood pressure, but it’s also been used off-label for decades to ease opioid withdrawal symptoms. Opioid withdrawal symptoms can be extremely ...

The U.S. Food and Drug Administration (FDA) issued new labeling requirements for opioid pain medications on Thursday, adding a warning about potential drug-induced reactions such as a rise in pain or ...

The opioid crisis refers to the rapid increase in opioid overuse, misuse, and overdose deaths since the 1990s. It involves both prescription opioids and opioids that people use recreationally. People ...

Opioids slot into opioid receptors and activate them. This sends signals to your brain to relieve pain and promote pleasure. Both endogenous opioids, which your body naturally produces, and exogenous ...

Opioid receptors are proteins in the nervous system that interact with opioids. Opioid receptors are part of the endogenous opioid system. This is the body’s internal system for regulating pain, ...