Scientists from Duke-NUS Medical School and their international collaborators have developed a new computational tool that ...

Northwestern Medicine scientists have uncovered a surprising link between a tiny cellular engine and the way cancer cells build the DNA they need to proliferate, according to a new study published in ...

Adenylosuccinate lyase (ADSL) deficiency is an inherited metabolic disorder that impairs purine metabolism. ADSL is a key enzyme in both the de novo synthesis and the purine nucleotide cycle, ...

A novel computational tool has been used to identify a metabolic weakness in acute myeloid leukemia, offering a new drug ...

Purine nucleotides are essential for cell growth and function as they serve as nucleic acid building blocks, signaling molecules, and energy carriers. Treatments that inhibit their synthesis offer a ...

While most enzymatic activity is conducted through chemical binding interactions between molecules, in some cases, the mere presence of an enzyme can affect intracellular functions. While exploring ...

A world-first discovery, published in the journal Science, rewrites our understanding of how cells control the production of DNA’s building blocks - and how this process affects the response to widely ...

Northwestern Medicine scientists have uncovered a surprising link between a tiny cellular engine and the way cancer cells build the DNA they need to proliferate, according to a new study published in ...

Parkinson's disease (PD), the second most common neurodegenerative disorder globally, has long baffled scientists with its progressive nature and debilitating effects on motor function. A recent study ...

NUDT5 enzyme acts as a molecular scaffold that maintains metabolic balance. Inside every cell, a finely tuned metabolic network determines when to build, recycle or stop producing essential molecules.