This pragmatic randomized controlled trial aimed to assess the effect of a passive display of artificial intelligence (AI)-based predictive analytics on hours free of clinical deterioration events ...
The US Food and Drug Administration (FDA) has revised a 2023 draft guidance on master protocols for drug and biological ...
Science faces a reproducibility crisis, and public trust in science declines when large clinical trials, which had been qualified by promising preclinical studies, fail. While some clinical trial ...
Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...
Despite guideline recommendations, evidence for the use of non–vitamin K antagonist oral anticoagulant (NOAC) monotherapy in patients with atrial fibrillation after implantation of a drug-eluting ...
Breakthrough Designation: Pivotal Trials Lack Randomization, Double-Blinding and Control Groups A review of all therapeutics receiving a breakthrough designation and approved from 2012 to 2017 found a ...
A randomized phase 2 peri-operative (neoadjuvant plus adjuvant) study of fianlimab (anti–LAG-3) plus cemiplimab (anti–PD-1) versus anti–PD-1 alone in patients with resectable stage III and IV melanoma ...
Improving clinical trial interpretability and efficiency: A Bayesian re-analysis of individual patient outcomes from 230 phase III oncology trials. Kaleido registry: A multi-center registry platform ...
A large real-world clinical trial has found that a generative AI-powered support tool used to support frontline clinicians was safe and improved the quality of clinical decision-making, but did not ...
A New York Times health reporter explains what clinical trials are, why they are important and how they can help inform us. Credit...Ricardo Tomás Supported by By Nina Agrawal Nina Agrawal is a health ...
When you think of clinical trials for cancer, testing a new medication may come to mind. But drugs aren’t the only thing these trials investigate. There’s a growing world of nonpharmaceutical clinical ...
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