Gut

Risk-based pathology reporting after endoscopic submucosal dissection for early gastrointestinal cancer: international consensus standards

Background Endoscopic submucosal dissection (ESD) enables en bloc resection of early gastrointestinal cancers and provides ...
Gut

Serum creatinine as both yardstick and predictor: reading chronic kidney disease in the global CLEARED cohort

We read the global analysis of chronic kidney disease (CKD) in cirrhosis by Wong et al with great interest.1 Assembling 7040 ...
Gut

Decoding intestinal metaplasia: a step towards understanding gastric tumourigenesis

Tissue epithelia maintain their lineage identity under normal conditions but occasionally undergo ‘reprogramming’ into ...
gut.bmj

The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers

Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK Correspondence to: Dr L A Houghton, Department of Medicine, University Hospital of South Manchester, Nell Lane, ...
gut.bmj

Twenty-four-week anti-PD-1 antibody regimen promoted HBsAg reduction and concurrently enhanced HBV-specific T cell responses in patients with chronic hepatitis B

Background PD-1 blockade has emerged as a promising approach for functional cure of chronic hepatitis B (CHB). Objective This study aimed to evaluate the safety profile of anti-PD-1 antibody (αPD-1), ...
gut.bmj

Early high-energy enteral nutrition in acute pancreatitis: overfeeding and respiratory risk in high-risk patients

I read the GOULASH trial with great interest. This multicentre, double-blind randomised clinical trial compared early high-energy enteral nutrition (30 kcal/kg/day) with a gradually increasing energy ...
gut.bmj

Acute lower GI bleeding in the UK: patient characteristics, interventions and outcomes in the first nationwide audit

5 National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford University Hospitals and the University of Oxford, Oxford, UK Objective Lower GI bleeding (LGIB) is a common ...
gut.bmj

Gut microbial-derived N-acetylmuramic acid alleviates colorectal cancer via the AKT1 pathway

Background Gut microbial metabolites are recognised as critical effector molecules that influence the development of colorectal cancer (CRC). Peptidoglycan fragments (PGFs) produced by microbiota play ...
gut.bmj

Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts

1 Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, ...
gut.bmj

Design and validation of a patient-reported outcome measure scale in acute pancreatitis: the PAN-PROMISE study

Objective This study aimed to develop and validate a patient-reported outcome measure (PROM) in acute pancreatitis (AP) as an endpoint centred on the patient. Design A PROM instrument ...
gut.bmj

Endoscopic mucosal biopsies are useful in distinguishing granulomatous colitis due to Crohn’s disease from tuberculosis

Dr A B Pulimood, Department of Surgery, School of Surgical Sciences, Medical School, University of Newcastle, Newcastle-upon-Tyne NE2 4HH, UK. BACKGROUND Intestinal tuberculosis and Crohn’s disease ...
gut.bmj

Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis

Bacterial infection is a frequent trigger of acute-on-chronic liver failure (ACLF), syndrome that could also increase the risk of infection. This investigation evaluated prevalence and characteristics ...