Emergency services say at least 12 people died and 45 were injured when a bus overturned on a highway in the South African city of Johannesburg.

Ministry spokesman Collen Msibi said 12 people died at the scene and four at a hospital. Msibi said reports indicated that 11 passengers were critically injured and 24 had moderate to serious

A bus lost control and flipped on a highway early Tuesday near Johannesburg's international airport, killing 16 as some were thrown from the vehicle, the transport ministry said.

A bus overturned near Johannesburg's OR Tambo International Airport early Tuesday, resulting in 12 deaths and 45 injuries. The bus was carrying passengers from Katlehong. Emergency responders attended the scene.