Seattle presents many challenges, but one of the most difficult matchups is with wide receiver Jaxon Smith-Njigba, who isn’t a household name yet in his third year out of Ohio State but probably should be. The Seahawks felt good enough about him to trade D.K. Metcalf, their No. 1 receiver, to Pittsburgh in the offseason.

It doesn’t sound San Francisco 49ers offensive lineman Trent Williams is likely to play against the Seahawks on Saturday, but so far the Niners are refusing to rule their left tackle out.

Wednesday was the second practice day of the week for both teams, and both teams produced a practice report that sheds some light on who will be available this weekend.

San Francisco 49ers defensive coordinator Robert Saleh was clear about the issues that would be created if he used man-to-man coverage against Seattle's prolific Jaxon Smith-Njibga.

Jauan Jennings and Brock Purdy, the 49ers’ seventh-round superstars, are a red-hot tandem entering Saturday night’s game against Seattle for the NFC playoffs’ top seed.

Seattle and San Francisco will decide the NFC West in Week 18. Check our NFL odds series for the Seahawks-49ers prediction and pick.

Sam Darnold and the Seahawks have won six in a row to take a one game lead into the final game of the regular season. Seattle is outscoring its opponents 29-18. Their stifling defense has allowed just 31 touchdowns through 16 games including just one last weekend in Charlotte to the Carolina Panthers in a 27-10 win.

With the final week of the regular season upon us, three teams from the NFC West are in the top five in the odds to win the Super Bowl. The Los Angeles Rams, the favorites for the last several weeks, are now tied with the Seattle Seahawks (+550), while the surging San Francisco 49ers are +850.

Chicago Bears tight end Colston Loveland had a great response to the team's rough loss to the San Francisco 49ers.

Teams that have started Sam Darnold have gone 27-6 in the past two seasons. However, the Minnesota Vikings saw Darnold start to fade before his worst two games closed out the season and the San Francisco 49ers are hoping to get the same outcome in Week 18 this year .