San Francisco star tight end George Kittle will miss the 49ers' key game in playoff positioning on Sunday night against the Chicago Bears with an ankle injury.

The San Francisco 49ers caught a tough injury break involving left tackle Trent Williams during a big game against the Chicago Bears.

San Francisco 49ers left tackle Trent Williams suffered a right hamstring injury in the first quarter Sunday against the Chicago Bears, and was replaced on the line by Austen Pleasants, who had played only 12 offensive snaps this season before the game.

With the San Francisco Pro Bowl tight out with a bad ankle, his wife won off the field for Sunday Night Football vs. the Chicago Bears.

The San Francisco 49ers defense hasn't been great on Sunday night against the Chicago Bears, and now they've lost a young defender.

Greg Papa’s return to the San Francisco 49ers radio broadcast booth will not happen on Sunday night. The beloved announcer and KNBR radio host confirmed a report by NBC Sports Bay Area that he would not be in the booth for the 49ers game against the Chicago Bears.

SANTA CLARA, CALIFORNIA - DECEMBER 28: Gymnast Simone Biles photographs from the sidelines before the game between the San Francisco 49ers and the Chicago Bears at Levi’s Stadium on December 28, 2025 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images) ORG XMIT: 776323792

San Francisco 49ers running back Christian McCaffrey follows two perfect blocks en route to a 5-yard touchdown run.