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Why can’t we edit genes in an embryo? Three reasons, and none of them are because “we don’t know how.” \t1\tHeritability. Casgevy edits blood cells, so the change dies with the patient. An embryo edit lands in every cell, including sperm and eggs. It’s permanent across generations, and nobody downstream consented. \t2\tMosaicism. CRISPR doesn’t edit a single cell embryo cleanly before it divides. He Jiankui’s 2018 twins came out as a patchwork. Some cells edited, some not. And most of the embryo
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