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Opioid agonists produce analgesia by binding to G protein-coupled receptors (GPCRs) in the brain and spinal cord regions involved in the transmission and modulation of pain Opioid drugs mimic endogenous compounds: endorphins, enkephalins, and dynorphins that bind to opioid receptors. Four opioid receptor types: mu (μ), kappa (κ), delta (δ ...
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